Growth Factor-9 Reviews
Created by Novex Biotech, Growth Factor-9 is a complex hormone antecedent designed to increase HGH secretion like other HGH supplements you see out there.
According to advertisements, “Growth Factor-9 changes everything . . . Unlike injectables, GF-9 doesn’t replace natural HGH, but rather uses a key amino acid blend to stimulate the body’s own production of this essential hormone.”
But is Growth Factor-9 a good supplement?
What’s Under the Lid?
Growth Factor-9’s formula only offers a few amino acids for boosting HGH production, and they’re mixed into a 2.9 g blend:
L-Arginine HCI. This amino acid is popularly used in muscle building supplements because it increases nitric oxide production for improved blood flow and circulation.
Studies show 5-9 grams arginine increases resting growth hormone levels by 100%.  Growth Factor-9, however, only contains 2.9 grams in its proprietary blend, which is not nearly enough to improve HGH production.
L-Lysine HCI. This amino acid is often used to treat viruses and boost immunity. Studies show a combination of 1200 mg lysine and 1200 mg arginine provoke a “release of pituitary somatotropin and insulin.” This in turn increases HGH production. Interestingly enough, these amino acids do not increase HGH production on their own in these doses. 
It’s possible that Growth Factor-9 contains enough of these two ingredients to improve HGH production. However, these two ingredients are combined with four others chosen to promote HGH. If Growth Factor 9 has a balance between all of them, then it’s not likely to have high enough concentrations to be effective.
N-Acetyl L-Cysteine. Cysteine is a powerful antioxidant and muscle builder. NAC is a more stable cysteine form. It has two metabolites: glutathione and glutathionine peroxidase. Low glutathione levels interfere with the body’s abilities to properly utilize HGH. There are not enough studies to determine if cysteine supplementation promotes HGH production.
L-Glutamine. Glutamine is the most abundant amino acid in muscle tissue. It increases protein synthesis and supports a healthy immune system. Research reveals glutamine supplementation increases plasma bicarbonate and circulating plasma growth hormone concentrations.  However, the study featured 2 grams glutamine and Growth Factor-9 only has 2.9 grams in its entire blend.
Oxoproline. This amino acid is derived from glutamic acid. There is not enough research on Oxoproline’s effects on HGH to validate its effectiveness.
Schizonepeta (Aerial Parts) Powder. Schizonepeta is commonly used to treat cold and fever symptoms, and in low doses may boost the immune system. Animal studies suggest high Schizonepeta doses regulate cytokine release, which in turn inhibits inflammatory response. Human trials still need to be conducted, and there is not enough information to determine if Schizonepeta affects HGH production.
Are The Ingredients Safe?
Most of the ingredients in Growth Factor-9 are amino acids, which are typically considered safe to use. However, this does not mean that Growth Factor-9 is completely safe to use.
For example, high arginine doses may result in abdominal pain, bloating, diarrhea, gout, blood abnormalities, and low blood pressure.
Similarly, Lysine is known to cause stomach pain and diarrhea.
Schizonepeta have not been fully researched, so its potential side effects and risks are currently unknown.
Most consumers who love their results find that the benefits outweigh the potential side effects.
Skyler_mims at GNC.com wrote, “bad side [effect] for me is it gives some [aches] and pains but nothing to bad. so far i like the results and will continue taking”
However, if you are taking medication, please consult your doctor before using Growth Factor-9.
Is Growth Factor-9 a Steroid?
Many people confuse hormone secretagogues with actual hormones found in steroids. Steroids use synthetic or artificial hormones to enhance muscle building. Secretagogues, on the other hand, use natural amino acids and ingredients that work with the body to stimulate hormone production.
Growth Factor-9 is not a steroid. It works with the body to increase hormone production and is completely legal to use.
How to Use Growth Factor-9
According to the label, adults should take 4 capsules on an empty stomach, either in the morning 2 hours before breakfast or 2 hours after dinner prior to bedtime.
Do not exceed 4 capsules in a 24 hour time period.
What Consumers are Saying
I found it interesting that most consumers either loved or hated Growth Factor-9, there was very little middle ground. Even more interesting, is that individuals who regularly worked out often experienced few (if any results) while those who led sedentary lifestyles found it improved mental focus.
For example, Ejlib at GNC.com wrote, “Keep in mind I am a “hard-gainer,” but I had no results from this product. As directed, I took 4 capsules on an empty stomach every night before bed for 30 days straight (the entire bottle) while following a 4-day/week lifting program and noticed no change whatsoever in weight or muscle measurements. I would be frustrated enough that I had no tangible results from the weight-lifting and nutrition/protein but the fact I had spent the money on this as well made it worse.”
But FredC also wrote at GNC.com, “This product is great. It really works. I am not really one that works out but I know a few that do. For me it helped me concentrate and survive some long hours at work. I also got smoother skin and more muscle tone. I liked it so much I started selling it.”
Growth Factor-9 can be purchased from the following sites:
• NovexBiotech.com: $99
• GNC.com: $99.99
• eVitamins.com: $99.99
What About Returns?
According to NovexBiotech.com, there is a 100% money-back guarantee. Unfortunately, there is no terms and conditions page to explain the parameters of the guarantee. It could be a 30 day guarantee on unopened products, or it could be a lifetime guarantee on a fully used bottle. All I have to go on is the money-back guarantee logo at the top of the page.
GNC.com, however, does issue 30 day satisfaction guarantees on all products sold on their site. If you are not satisfied, contact customer support.
Should You Try Growth Factor-9?
I’m not entirely sold on Growth Factor-9. Although the ingredients are based on clinical research, the formula is listed as a proprietary blend, so it’s impossible to know if the ingredients are used correctly.
The consumer reviews are mixed. While some users loved it, others did not.
Which brings us to price. . .
Growth Factor-9 is available for a fraction of the cost of HGH injections, but it’s still a hefty price tag for most users. $99 for a supplement that doesn’t guarantee results is not a gamble I’m willing to pay. Consequently, I do not feel comfortable recommending Growth Factor-9 at this time.
 Kanaley JA. “Growth hormone, arginine and exercise.” Current Opinion in Clinical Nutrition & Metabolic Care. 2008 Jan;11(1):50-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18090659
 Isidori A, Lo Mocao, Cappa M. “A study of growth hormone release in man after oral administration of amino acids.” Current Medical Research & Opnion. 1981;7(7):475-81.
 Welbourne TC. “Increased plasma bicarbonate and growth hormone after an oral glutamine load.” American Journal of Clinical Nutrition. 1995 May;61(5):1058-61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7733028
 Kang, H; Oh, YJ; Choi, HY; Ham, IH; Bae, HS; Kim, SH; Ahn, KS (2008). “Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro”. The Journal of pharmacy and pharmacology 60 (7): 901–7. doi:10.1211/jpp.60.7.0012. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18549677